Dr. Balaz’s research is oriented towards the development of experimental and computational methods for determining drug disposition and receptor binding. 在性格, his lab performs experimental measurements using (1) surrogate phases to find structural determinants of transbilayer transport rates and accumulation in membranes and triglyceride phases, and (2) binding to prevalent human proteins such as albumin and extracellular matrix components. The data is used to develop structure-based models for predicting the volume of distribution and other pharmacokinetic characteristics. One of the major goals of this work is to find ways to tailor drug structures for limited distribution, thereby reducing the cytotoxicity of drugs such as those used in treating some cancers or arthritis.
Dr. Cioffi is a medicinal chemist with extensive experience in integrated drug discovery working on research programs in support of large pharma, 生物技术, 学术, 和国家卫生研究院合作. He has made significant drug design contributions to programs spanning multiple therapeutic indications (e.g., 血脂异常, 肠易激综合症, 中枢神经系统, and ophthalmology) and has helped advance drug candidates into pre-clinical development and clinical trials. 2018年,博士. 乔菲被任命为一项 三年,1美元.4500万NIH研究经费 aimed at developing novel drug compounds for treating Age-related Macular Degeneration (AMD), a leading cause of vision loss in people age 50 and older.
Dr. Dearborn’s research focuses on development neurobiology in the fruit fly (Drosophila) in three primary areas: 1) The elucidation of vitamin D3 up-regulated protein 1 (VDUP1) tumor suppressor function during brain development, 包括VDUP1在神经干细胞生物学中的作用, 2) Hedgehog (Hh)-dependent regulation of VDUP1 in cell proliferation, including how tumor cell-specific differences in Hh signaling affect pharmacological treatment strategies, and 3) Molecular characterization of Eph receptor signaling pathways, 哪一个调节轴突引导, 血管生长, 和肿瘤发生. The lab emphasizes molecular-genetic approaches in these studies, 每一个都具有临床和翻译相关性.
Dr. 哈斯的研究整合了合成有机化学, 药物配方及稳定性, 生化检测, 药物化学, 和药理学. Her laboratory provides training opportunities for students in the areas of drug synthesis, 制药配方, 局部给药, 并对药物疗效进行评估. A major area of focus is the synthesis and activity of new drugs for use as topical agents to treat skin diseases. One group of novel co-drugs is designed to replenish natural antioxidants in the skin for enhanced and extended photoprotection relative to existing topical products. Other topical agents under development utilize the co-drug approach to target hyperproliferation of keratinocytes and inflammation associated with psoriasis.
关于 70% of estrogen receptor (ER) positive breast cancers have a significantly reduced risk of invasive breast cancer through the use of various endocrine therapies. Despite the relative safety and significant anti-neoplastic and chemopreventive activities of tamoxifen and aromatase inhibitors, many initially responsive breast tumors develop resistance and ultimately recur. My current research is to investigate the secretome leading to the endocrine resistance in crosstalk between endocrine resistant breast cancer and tumor microen梵onment. The long-term mission of my laboratory is to understand the steps of the endocrine resistant process in order to develop therapeutic approaches to prevent and treat endocrine resistant breast cancer effectively. The ultimate goal of my research is to bring therapies into the clinic that will improve the survival of metastatic breast cancer patients.
Dr. LaRocca’s research interest lies primarily in the mechanisms of eukaryotic programmed cell death or PCD. 这包括细胞凋亡的过程, necroptosis, and the molecular switches that balance the two pathways. Dr. LaRocca is particularly interested in the role of glucose in driving PCD. He is actively investigating the mechanism of hyperglycemic cell death and its role in the exacerbation of ischemic brain injury (stroke). 他实验室的第二个项目是 an NIH-funded grant aimed at improving understanding of a type of red blood cell death called necroptosis and exploring ways to influence this process. Results from this work could one day lead to improved treatments for patients suffering from bacterial blood infections and other blood related disorders.
博士的长期研究目标. Malik’s laboratory is to understand the complexities of host pathogen interactions for the development of improved prophylactics and therapeutics against important bacterial infections. 她有一个 由国立卫生研究院提供的三年资助 to investigate the mechanisms by which Francisella tularensis, a category A biothreat agent survives inside the immune cells and suppresses the protective immune responses. A second area of focus is investigating the molecular mechanisms leading to the development of antibiotic resistance in methicillin resistant Staphylococcus aureus (MRSA) strains. 单击以下的PubMed链接 additional information on research projects taking place in Dr. 马利克的实验室.
Dr. Mousa's current research interest is focused on advancing novel concepts in therapeutic and diagnostic targets through the exploration of the role of cell adhesion molecules and extracellular matrix proteins, 血管生成, 血栓形成, 以及健康和疾病中的炎症调节. 为此, 促进科技，包括纳米科技, 生物技术, 药物治疗, and stem cells serve as key catalysts in the discovery of novel therapeutics and diagnostics for the treatment and prevention of various diseases including oncological, 心血管, 神经系统, 眼科, 炎症, 以及其他血管疾病. 参观 药物研究所网站 了解更多关于当前项目和计划的信息.
Dr. Musteata's research interests include the development of miniaturized analytical technology for
pharmacokinetic studies and therapeutic drug monitoring, 以创造个性化治疗为目的
devices that integrate chemical analysis, decision, and drug delivery.
在博士工作. 沙阿的实验室涉及结构生物学. He is currently investigating genetic polymorphisms in drug metabolizing Cytochrome P450 (CYP) enzymes using structural and biophysical methods. CYP's constitute the major enzyme family in drug metabolism, and single nucleotide polymorphisms with amino acid substitutions are important contributors to interindividual variability in drug response. 在短暂的, recombinant protein expression and purification are carried out in the laboratory in order to produce the quantities of CYP protein necessary for crystallization. 晶体学数据是远程收集的, and the three dimensional structure of the protein is then elucidated using computational tools.
Dr. Shi’s research interests are mainly focused on understanding the molecular basis of disease pathogenesis by using advanced molecular biology, 病毒学, 分子遗传学, 和生物信息学方法. Methods used in his lab include a) HIV-1 infectious molecular clone, 重组病毒, and reporter gene technologies to study HIV phenotypes such as infection and replication; b) HIV-1 single genome amplification, sequencing and bioinformatics tools to understand genotype changes and their association with disease progression. 博士感兴趣的另一个主要领域. Shi’s lab is the design and development of diagnosis assays for detecting infectious diseases, 监测疾病进展, 治疗和管理.
Dr. Singh has an extensive scientific background in studying molecular mechanisms associated with HIV pathogenesis, 基因组印记, 分子生物学和小鼠疾病模型. Dr. Singh’s research interests include investigating the underlying molecular mechanisms involved in- i) HIV associated 神经系统 disorder, (二)HIV延迟, and iii) Viral infection induced developmental defects. 目前,博士. Singh’s lab is focused at investigating two projects that come under NIH HIV/AIDS high priority research topics. Project 1: To investigate the consequences of HIV (Human Immunodeficiency Virus) mediated downregulation of Sonic hedgehog (Shh) signaling on brain homeostasis with specific focus on aberrant communication between astrocytes and other brain-resident cells (brain endothelial cells, 的周, 小胶质细胞和神经元). Project 2: To characterize select noncoding RNAs for their potential to establish HIV latency via- i) mediating Interferon signaling, and ii) regulating expression of HIV genome by epigenetic mechanisms. Successful completion of these studies will identify novel targets to alleviate HIV pathogenesis as well as pave the way towards HIV cure.
VDUP-1 (TBP-2) is a protein whose expression is decreased in tumors and increased following treatment with Vitamin D. VDUP-1是硫氧还蛋白的抑制剂, 与许多转录因子相互作用. Dr. Voigt is currently investigating the role of VDUP-1 in regulation of transcription factor activity and cell proliferation/differentiation in different cell types.
博士研究. Yager’s laboratory is focused on understanding how the body regulates 炎症 responses during flu infection. Recent studies have established a critical role for the multi-protein cytosolic NLPR3 inflammasome complex in host defense and pathophysiology during flu infection. 具体来说,博士. Yager and his team are investigating how NLRP3 inflammasome activation and resultant 炎症 cytokine secretion are regulated on a molecular level to favor host protection over immunopathology. Other areas of research include the identification of novel targets for the development of new anti-梵al drugs to combat flu infection and the role of 梵al-induced inflammation in the etiology and pathogenesis of autism spectrum disorder.
Dr. Zheng’s research group is interested in the design and evaluation of Complex Drug Products (CDP) that are made of botanicals, 肽, 以及来自自然的蛋白质. Interdisciplinary technologies and translational strategies are used to ensure pharmaceutical quality, 阐明作用机制, 评估临床效益和风险. These efforts can help empower regulatory decisions and enable patient-centric product design. Current projects in the lab focus on assessing the risks and benefits of medical cannabis products. This includes studying the effects of botanical and endogenous cannabinoids on the brain and the blood brain interface (BBI) as well as investigating the endocannabinoid system (ECS) on drug delivery barriers.